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PLoS One ; 15(6): e0232831, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32497096

RESUMO

The burden of enteric pathogens in poultry is growing after the ban of antibiotic use in animal production. Organic acids gained attention as a possible alternative to antibiotics due to their antimicrobial activities, improved nutrient metabolism and performance. The current study was conducted to evaluate the effectiveness of organic acid blend on broilers cecal microbiota, histomorphometric measurements, and short-chain fatty acid production in Salmonella enterica serovar Typhimurium challenge model. Birds were divided into four treatments, including a negative control, positive control challenged with S. Typhimurium, group supplemented with an organic acid blend, and birds supplemented with organic acid blend and Salmonella challenged. Results illustrate significant differences in feed conversion ratios and production efficiency factor between treatment groups, however, the influence of organic acid supplement was marginal. Organic acid blend significantly increased cecal acetic and butyric acids concentrations when compared to unsupplemented groups and resulted in minor alterations of intestinal bacterial communities.


Assuntos
Acetatos/metabolismo , Ração Animal , Butiratos/metabolismo , Galinhas/microbiologia , Suplementos Nutricionais , Ácidos Graxos/farmacologia , Microbioma Gastrointestinal/efeitos dos fármacos , Doenças das Aves Domésticas/terapia , Salmonelose Animal/terapia , Salmonella typhimurium/efeitos dos fármacos , Animais , Ceco/microbiologia , Galinhas/metabolismo , Ácidos Graxos/administração & dosagem , Ácidos Graxos Voláteis/administração & dosagem , Ácidos Graxos Voláteis/farmacologia , Íleo/metabolismo , Íleo/ultraestrutura , Mananas/administração & dosagem , Microvilosidades/ultraestrutura , Doenças das Aves Domésticas/microbiologia , Doenças das Aves Domésticas/prevenção & controle , Distribuição Aleatória , Salmonelose Animal/microbiologia , Salmonelose Animal/prevenção & controle , Salmonella typhimurium/isolamento & purificação , Salmonella typhimurium/metabolismo
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